GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.
Properties:
Density: 1.318g/cm3
Boiling Point: 567.985ºC at 760 mmHg
Flash Point: 297.307ºC
Refractive Index: 1.708
Trk receptor Inhibitors Related Products:
SP600125; Danusertib; Altiratinib; GNF-5837; Ropotrectinib; Larotrectinib sulfate; Entrectinib; ANA-12