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GSK2126458 Omipalisib

GSK2126458 Omipalisib 1086062-66-9
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Chemical Information
Product name:GSK2126458 Omipalisib Purity:98% min
CAS NO:1086062-66-9 Solubility:10 mM in DMSO
Molecular Formula:C25H17F2N5O3S Package:Package according to customer requirements
Molecular Weight:505.496 Storage:Store at -20℃
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Remarks
Omipalisib, also known as GSK2126458, is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor GSK2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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