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PIK-90 677338-12-4
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Chemical Information
Product name:PIK-90 Purity:98% min
CAS NO:677338-12-4 Solubility:DMSO : 1.75 mg/mL (4.98 mM)
Molecular Formula:C18H17N5O3 Package:Package according to customer requirements
Molecular Weight:351.359 Storage:Store at -20℃
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PIK-90 is a potent PI3K inhibitor with potential anticancer activity.
PIK-90 shows distinct patterns of isoform selectivity to inhibit different subsets of four class I PI3K isoforms. In addition, PIK-90 completely inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. PIK-90 exhibits significantly antiproliferative activity by effectively blocking phosphorylation of Akt in six glioma cell lines varying in mutational status at PTEN or p53, including U87 MG, SF188, SF763, LN229, A1207 and LN-Z30 cells. 
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