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BKM120 Buparlisib

BKM120 Buparlisib 944396-07-0
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Chemical Information
Product name:BKM120 Buparlisib Purity:98% min
CAS NO:944396-07-0 Solubility:DMSO : ≥ 100 mg/mL (243.67 mM)
Molecular Formula:C18H21F3N6O2 Package:Package according to customer requirements
Molecular Weight:410.394 Storage:Store at -20℃
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Buparlisib, also known as BKM120, is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. PI3K inhibitor BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway.
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