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Pictilisib mesylate

Pictilisib mesylate 957054-33-0
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Chemical Information
Product name:Pictilisib mesylate Purity:98% min
CAS NO:957054-33-0 Solubility:10 mM in DMSO
Molecular Formula:C25H35N7O9S4 Package:Package according to customer requirements
Molecular Weight:705.835 Storage:Store at -20℃
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Remarks

Pictilisib, also known as Pictrelisib, GDC-0941, RG7321 and GNE0941 , is an orally bioavailable, and is a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) isoforms p100alpha and p100delta with potential antineoplastic activity. PI3K inhibitor GDC-0941 selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway; inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations may result.

GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).

 

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