BIX02189

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Chemical Information

Product name：BIX02189	Purity：98% min
CAS NO：1094614-85-3	Solubility：DMSO: ≥ 49.4 mg/mL
Molecular Formula：C₂₇H₂₈N₄O₂	Package：Package according to customer requirements
Molecular Weight：440.537	Storage：Store at -20℃

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Remarks

BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. BIX02189 was reported to inhibit catalytic function of purified, MEK5 enzyme. BIX02189 blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. BIX02189 also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system. BIX02189 may offer novel pharmacological tools to better characterize the role of the MEK5/ERK5 pathway in various biological systems.

ERK Inhibitors Related Products:

Resveratrol; SCH772984; Pluripotin; VX-11e; DEL-22379; Ulixertinib; Ravoxertinib; XMD8-92; Bosutinib; ERK5-IN-1; ONC-201; AZD-0364

References

[1]. Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.

[2]. Hwang AR, et al. Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells. PLoS One. 2017 May 22;12(5):e0178278.

[3]. Kim M, et al. Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J Biol Chem. 2012 Nov 23;287(48):40722-31.