AZD0364 is an ERK1 and/or ERK2 kinase for the treatment of cancer. ERK1 and ERK2 kinases are ubiquitously expressed MAPK kinases that participate in the RAS-RAF-MEK-ERK signalling cascade in the regulation of cell cycle progression, cell proliferation, survival, metab. and transcription. The RAS-RAF-MEK-ERK signalling cascade is deregulated in a variety of diseases including brain injury, cancer, cardiac hypertrophy, diabetes, and inflammation. In particular the RAS-RAF-MEK-ERK signalling cascade is an attractive pathway for anti-cancer therapies across a broad range of human tumors.
ERK Inhibitors Related Products:
BIX02189; Resveratrol; SCH772984; Pluripotin; VX-11e; DEL-22379; Ulixertinib; Ravoxertinib; XMD8-92; Bosutinib; ERK5-IN-1; ONC-201