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VRT752271 Ulixertinib

VRT752271 Ulixertinib 869886-67-9
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Chemical Information
Product name:VRT752271 Ulixertinib Purity:98% min
CAS NO:869886-67-9 Solubility:DMSO : ≥ 45 mg/mL (103.85 mM)
Molecular Formula:C21H22Cl2N4O2 Package:Package according to customer requirements
Molecular Weight:433.331 Storage:Store at -20℃
Quality control
Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
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