VX-11e

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Chemical Information

Product name：VX-11e	Purity：98% min
CAS NO：896720-20-0	Solubility：DMSO : ≥ 100 mg/mL (199.86 mM)
Molecular Formula：C₂₄H₂₀Cl₂FN₅O₂	Package：Package according to customer requirements
Molecular Weight：500.352	Storage：Store at -20℃

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Remarks

VX-11e (VTX-11e, Vertex-11e) is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.

Chemical Name:

4-[2-(2-chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

ERK Inhibitors Related Products:

BIX02189; Resveratrol; SCH772984; Pluripotin; DEL-22379; Ulixertinib; Ravoxertinib; XMD8-92; Bosutinib; ERK5-IN-1; ONC-201; AZD-0364

References

[1]. Aronov, Alex M., et al. Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control. Journal of Medicinal Chemistry (2009), 52(20), 6362-6368.

[2]. Krepler C, et al. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.