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PF299804 Dacomitinib

PF299804 Dacomitinib 1110813-31-4
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Chemical Information
Product name:PF299804 Dacomitinib Purity:98% min
CAS NO:1110813-31-4 Solubility:DMSO: ≥ 50 mg/mL (Need ultrasonic)
Molecular Formula:C24H25ClFN5O2 Package:Package according to customer requirements
Molecular Weight:469.939 Storage:Store at -20℃
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Remarks
Dacomitinib, aslo known as PF-299 and PF-00299804 ; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.
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