A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Properties:
Appearance & Physical State: yellow solid
Density: 1.337g/cm3
Melting Point: 215ºC
Boiling Point: 615.2ºC at 760mmHg
Flash Point: 325.9ºC
EGFR Inhibitors Related Products:
Erlotinib; Erlotinib hcl; Gefitinib; Dacomitinib; WZ4002; Pelitinib; Brigatinib analog; Allitinib; Rociletinib; Varlitinib; Icotinib; WHI-P154; CNX-2006; AG-18; Nazartinib