Product :
WZ4002
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Chemical Information
Product name:WZ4002 |
Purity:98% min |
CAS NO:1213269-23-8 |
Solubility:10 mM in DMSO |
Molecular Formula:C25H27ClN6O3 |
Package:Package according to customer requirements |
Molecular Weight:494.973 |
Storage:Store at -20℃ |
Remarks
WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.