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Product :

WZ4002

WZ4002 1213269-23-8
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Chemical Information
Product name:WZ4002 Purity:98% min
CAS NO:1213269-23-8 Solubility:10 mM in DMSO
Molecular Formula:C25H27ClN6O3 Package:Package according to customer requirements
Molecular Weight:494.973 Storage:Store at -20℃
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Remarks
WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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