Product :
WZ4002
Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Chemical Information
| Product name：WZ4002 |
Purity：98% min |
| CAS NO：1213269-23-8 |
Solubility：10 mM in DMSO |
| Molecular Formula：C25H27ClN6O3 |
Package：Package according to customer requirements |
| Molecular Weight：494.973 |
Storage：Store at -20℃ |
Remarks
WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.