AG-18 Tyrphostin A23

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Chemical Information

Product name：AG-18 Tyrphostin A23	Purity：98% min
CAS NO：118409-57-7	Solubility：DMSO : ≥ 50 mg/mL (268.57 mM)
Molecular Formula：C₁₀H₆N₂O₂	Package：Package according to customer requirements
Molecular Weight：186.167	Storage：Store at -20℃

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Remarks

AG-18, also known as RG-50810; RG-50858; TX 825; Tyrphostin A23; Tyrphostin AG-18. AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431. AG-18 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.

EGFR Inhibitors Related Products:

Erlotinib; Erlotinib hcl; Gefitinib; AG-490; Dacomitinib; WZ4002; Pelitinib; Brigatinib analog; Allitinib; Rociletinib; Varlitinib; Icotinib; WHI-P154; CNX-2006; Nazartinib

References

[1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52.

[2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40.