Pelitinib(EKB569)

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Chemical Information

Product name：Pelitinib(EKB569)	Purity：98% min
CAS NO：257933-82-7	Solubility：DMSO : 16 mg/mL (34.19 mM)
Molecular Formula：C₂₄H₂₃ClFN₅O₂	Package：Package according to customer requirements
Molecular Weight：467.92	Storage：Store at -20℃

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Remarks

Pelitinib, also known as EKB569 and WAY-172569, is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.

EGFR Inhibitors Related Products:

Erlotinib; Erlotinib hcl; Gefitinib; AG-490; Dacomitinib; WZ4002; Brigatinib analog; Allitinib; Rociletinib; Varlitinib; Icotinib; WHI-P154; CNX-2006; AG-18 ; Nazartinib

References

[1]. Torrance CJ, et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med. 2000 Sep;6(9):1024-8.

[2]. Nunes M, et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes. Mol Cancer Ther. 2004 Jan;3(1):21-7.