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ARRY-543 Varlitinib

ARRY-543 Varlitinib 845272-21-1
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Chemical Information
Product name:ARRY-543 Varlitinib Purity:98% min
CAS NO:845272-21-1 Solubility:10 mM in DMSO
Molecular Formula:C22H19ClN6O2S Package:Package according to customer requirements
Molecular Weight:466.943 Storage:Store at -20℃
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Remarks
Varlitinib, also known as ARRY-543 and ASLAN001, is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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