ARRY-543 Varlitinib

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Chemical Information

Product name：ARRY-543 Varlitinib	Purity：98% min
CAS NO：845272-21-1	Solubility：DMSO : 50 mg/mL (107.08 mM)
Molecular Formula：C₂₂H₁₉ClN₆O₂S	Package：Package according to customer requirements
Molecular Weight：466.943	Storage：Store at -20℃

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Remarks

Varlitinib, also known as ARRY-543 and ASLAN001, is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types.

EGFR Inhibitors Related Products:

Erlotinib; Erlotinib hcl; Gefitinib; AG-490; Dacomitinib; WZ4002; Pelitinib; Brigatinib analog; Allitinib; Rociletinib; Icotinib; WHI-P154; CNX-2006; AG-18 ; Nazartinib

References

[1]. Hsieh C, et al. Varlitinib to demonstrate anti-tumour efficacy in patient-derived hepatocellular carcinoma xenograft models. Journal of Clinical Oncology 34, no. 15_suppl

[2]. Miknis G, et al. ARRY-334543, A potent, orally active small molecule inhibitor of EGFR and ErbB-2.Proc Amer Assoc Cancer Res, Volume 46, 2005