I-BET151 GSK1210151A

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Chemical Information

Product name：I-BET151 GSK1210151A	Purity：98% min
CAS NO：1300031-49-5	Solubility：DMSO : ≥ 100 mg/mL (240.71 mM)
Molecular Formula：C₂₃H₂₁N₅O₃	Package：Package according to customer requirements
Molecular Weight：415.445	Storage：Store at 2-8°C

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Remarks

GSK1210151A, also known as I-BET151, is a BET bromodomain inhibitor, which blocks recruitment of BET to chromatin. I-BET151 ( GSK1210151A ) shows good oral bioavailability in both the rat and minipig as well as demonstrating efficient suppression of bacterial induced inflammation and sepsis in a murine in vivo endotoxaemia model.

Chemical Properties:

density: 1.314

form: powder

pka: 11.14±0.20(Predicted)

color: white to beige

Epigenetic Reader Domain Inhibitors Related Products:

ICG-001; (+)-JQ1; PFI-1; Molibresib; Apabetalone; C646; Curcumin; Bromosporine; Birabresib; UNC1215; GSK6853; CPI-637; BI-9564; PFI-4; XMD8-92; MS436; CPI-203; KG-501; Mivebresib; GSK2801

References

[1]. Seal J, et al. Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72.

[2]. Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705.