UNC1215

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Chemical Information

Product name：UNC1215	Purity：98% min
CAS NO：1415800-43-9	Solubility：DMSO: ≥ 270 mg/mL
Molecular Formula：C₃₂H₄₃N₅O₂	Package：Package according to customer requirements
Molecular Weight：529.716	Storage：Store at 2-8°C

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Remarks

UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3.

Chemical Properties:

Boiling point: 712.1±60.0 °C(Predicted)

density: 1.224±0.06 g/cm3(Predicted)

form:powder

pka: 9.90±0.20(Predicted)

color: white to beige

Epigenetic Reader Domain Inhibitors Related Products:

ICG-001; (+)-JQ1; I-BET151; PFI-1; Molibresib; Apabetalone; C646; Curcumin; Bromosporine; Birabresib; GSK6853; CPI-637; BI-9564; PFI-4; XMD8-92; MS436; CPI-203; KG-501; Mivebresib ; GSK2801

References

[1]. James LI, Barsyte-Lovejoy D, Zhong N, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91. doi: 10.1038/nchembio.1157.