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UNC1215

UNC1215 1415800-43-9
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Chemical Information
Product name:UNC1215 Purity:98% min
CAS NO:1415800-43-9 Solubility:DMSO: ≥ 270 mg/mL
Molecular Formula:C32H43N5O2 Package:Package according to customer requirements
Molecular Weight:529.716 Storage:Store at -20℃
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Remarks

UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3.


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