KW-6002 Istradefylline

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Chemical Information

Product name：KW-6002 Istradefylline	Purity：99% min
CAS NO：155270-99-8	Solubility：DMSO : 25.33 mg/mL (65.89 mM)
Molecular Formula：C₂₀H₂₄N₄O₄	Package：Package according to customer requirements
Molecular Weight：384.429	Storage：Store at -20℃

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Remarks

Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease. Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drugs such as levodopa. Istradefylline is an analog of caffeine.

Properties:
Density: 1.24g/cm3
Boiling Point: 601ºC at 760mmHg
Flash Point: 317.3ºC
Refractive Index: 1.598
Vapor Pressure: 2.12E-14mmHg at 25°C

Adenosine Receptor Inhibitors Related Products:

Preladenant; Reversine; SCH-58261; ZM241385; Regadenoson; CGS-15943; Tozadenant; Adenosine amine congener (ADAC); CGS-21680; CGS-21680 HCl; Vipadenant

References

[1]. Chen JF, et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci. 2001 May 15;21(10):RC143.

[2]. Shiozaki S, et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999 Nov;147(1):90-5.