BIIB-014 Vipadenant

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Chemical Information

Product name：BIIB-014 Vipadenant	Purity：98% min
CAS NO：442908-10-3	Solubility：DMSO : ≥ 31 mg/mL (96.47 mM)
Molecular Formula：C₁₆H₁₅N₇O	Package：Package according to customer requirements
Molecular Weight：321.337	Storage：Store at -20℃

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Remarks

Vipadenant, also known as BIIB014, CEB-4520, is a potent, selective and orally available adenosine A2A receptor antagonist under development for for Parkinson's disease. Vipadenant demonstrates strong oral activity in commonly used models of Parkinson's disease. Vipadenant has shown excellent preclinical pharmacokinetics and has successfully completed phase I clinical studies.

Adenosine Receptor Related Products:

ZM241385; Preladenant; Reversine; SCH-58261; Istradefylline; Regadenoson; CGS-15943; Tozadenant; Adenosine amine congener (ADAC); CGS-21680; CGS-21680 HCl

References

[1]. Jones N, et al. A2A receptor antagonists do not induce dyskinesias in drug-naive or L-dopa sensitized rats. Brain Res Bull. 2013 Sep;98:163-9.

[2]. Brian C. Shook, et al. Adenosine A2A Receptor Antagonists and Parkinson’s Disease. ACS Chem Neurosci. 2011 Oct 19; 2(10): 555-567.