ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7 min) OGD period, and protect CA1 neuron and astrocyte from injury.
Chemical Properties:
density: 1.59±0.1 g/cm3(Predicted)
form: powder
pka: 10.03±0.15(Predicted)
color: white to tan
Adenosine Receptor Related Products:
Preladenant; Reversine; SCH-58261; Istradefylline; Regadenoson; CGS-15943; Tozadenant; Adenosine amine congener (ADAC); CGS-21680; CGS-21680 HCl; Vipadenant