SCH-58261

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Chemical Information

Product name：SCH-58261	Purity：98% min
CAS NO：160098-96-4	Solubility：DMSO : ≥ 34 mg/mL (98.45 mM)
Molecular Formula：C₁₈H₁₅N₇O	Package：Package according to customer requirements.
Molecular Weight：345.358	Storage：Store at -20℃

Quality control

COA

Remarks

SCH-58261 is a potent and selective adenosine A(2A) receptor antagonist. SCH-58261 is a useful ligand in autoradiographic studies. Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. SCH 58261 counteracts parkinsonian-like muscle rigidity in rats. SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat. SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.

Properties:
Density: 1.54g/cm3
Refractive Index: 1.807

Adenosine Receptor Related Products:

Preladenant; Reversine; ZM241385; Istradefylline; Regadenoson; CGS-15943; Tozadenant; Adenosine amine congener (ADAC); CGS-21680; CGS-21680 HCl; Vipadenant

References

[1]. Zocchi C, et al. Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes. Br J Pharmacol. 1996 Apr;117(7):1381-6.

[2]. Varani K, et al. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol. 1996 Apr;117(8):1693-701.