Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. Upon entry into cells, remdesivir is metabolized into the nucleotide triphosphate GS-441524. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h. GS-5734 inhibits both epidemic and zoonotic coronaviruses. It was developed as a treatment for filovirus infections such as Ebola virus disease and Marburg virus. Remdesivir was approved for treatment of COVID-19.
Antiviral Inhibitors Related Products:
Vadimezan; Geldanamycin; UNC0638; U0126-EtOH; Tenofovir; Baloxavir; Tubacin; NGI-1(ML414); Emricasan; Baloxavir marboxil; Famciclovir; Epigoitrin; Ribavirin