Geldanamycin

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Chemical Information

Product name：Geldanamycin	Purity：98% min
CAS NO：30562-34-6	Solubility：DMSO: ≥ 24 mg/mL
Molecular Formula：C₂₉H₄₀N₂O₉	Package：Package according to customer requirements
Molecular Weight：560.6359	Storage：Store at -20℃

Quality control

COA

Remarks

Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and inhibits its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. Hsp90-geldanamycin complex. PDB 1yet Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate (namely, hepatotoxicity) that have led to the development of geldanamycin analogues.

HSP (HSP90) inhibitor Related Prodcuts:

Tanespimycin; Luminespib; Alvespimycin; Ganetespib; BIIB021; Onalespib; NVP-BEP800; SNX-2112; PF-04929113; KW-2478; XL888; Zelavespib (PU-H71); KRIBB11; VER-50589; Triptolide; NVP-HSP990; Dimethylenastron

References

[1] Roe SM, et al, J Med Chem, 1999, 42(2), 260-266.

[2] Mcllwrath AJ, et al, Cancer Chemother Pharmacol, 1996, 37(5), 423-428.

[3] Mimnaugh EG, et al, J Biol Chem 1996, 271(37), 22796-22801.