VER-50589

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Chemical Information

Product name：VER-50589	Purity：98% min
CAS NO：747413-08-7	Solubility：DMSO : ≥ 48 mg/mL (123.46 mM)
Molecular Formula：C₁₉H₁₇ClN₂O₅	Package：Package according to customer requirements
Molecular Weight：388.802	Storage：Store at -20℃

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Remarks

VER-50589 is a potent Hsp90 inhibitor. VER-50589 inhibits Hsp90 with an IC50 value of 21 nM. It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel. VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals.

HSP (HSP90) inhibitor Related Prodcuts:

Tanespimycin; Luminespib; Alvespimycin; Ganetespib; BIIB021; Onalespib; NVP-BEP800; SNX-2112; PF-04929113; KW-2478; XL888; Zelavespib (PU-H71); KRIBB11; Triptolide; NVP-HSP990; Dimethylenastron ; Geldanamycin

References

[1]. Sharp SY, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther. 2007 Apr;6(4):1198-211.