SNX-2112 PF-04928473

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Chemical Information

Product name：SNX-2112 PF-04928473	Purity：98% min
CAS NO：908112-43-6	Solubility：93 mg/mL (200.22 mM)
Molecular Formula：C₂₃H₂₇F₃N₄O₃	Package：Package according to customer requirements
Molecular Weight：464.481	Storage：Store at -20℃

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Remarks

SNX-2112 is a selective heat shock protein 90 (Hsp90) inhibitor which can exert a potent anticancer activity. Studies demonstates that SNX-2112 can exhibit a potent anticancer activity against B16 melanoma cells both in vitro and in vivo, by inhibiting cell proliferation and inducing cell cycle arrest and apoptosis in a mechanism dependent on the degredation of Hsp90 client proteins.

HSP (HSP90) inhibitor Related Prodcuts:

Tanespimycin; Luminespib; Alvespimycin; Ganetespib; BIIB021; Onalespib; NVP-BEP800; PF-04929113; KW-2478; XL888; Zelavespib (PU-H71); KRIBB11; VER-50589; Triptolide; NVP-HSP990; Dimethylenastron ; Geldanamycin

References

[1] Chandarlapaty S, et al, Clin Cancer Res, 2008, 14(1), 240-248.

[2] Okawa Y, et al, Blood, 2009, 113(4), 846-855.

[3] Chinn DC, et al, Pediatr Blood Cancer, 2012, 58(6), 885-890.