NVP-HSP990

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Chemical Information

Product name：NVP-HSP990	Purity：98% min
CAS NO：934343-74-5	Solubility：DMSO : ≥ 33 mg/mL (86.98 mM)
Molecular Formula：C₂₀H₁₈FN₅O₂	Package：Package according to customer requirements
Molecular Weight：379.388	Storage：Store at -20℃

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Remarks

HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.

HSP (HSP90) inhibitor Related Prodcuts:

Tanespimycin; Luminespib; Alvespimycin; Ganetespib; BIIB021; Onalespib; NVP-BEP800; SNX-2112; PF-04929113; KW-2478; XL888; Zelavespib (PU-H71); KRIBB11; VER-50589; Triptolide; Dimethylenastron; Geldanamycin

References

[1]. Menezes DL, et al. The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. Mol Cancer Ther. 2012 Mar;11(3):730-9.

[2]. McBride CM, et al. Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990. J Med Chem. 2014 Nov 13;57(21):9124-9.