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ML414 790702-57-7
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Chemical Information
Product name:ML414 Purity:98% min
CAS NO:790702-57-7 Solubility:Soluble in DMSO
Molecular Formula:C17H22N4O3S2 Package:Package according to customer requirements
Molecular Weight:394.51 Storage:Store at -20℃
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NGI-1, also known s ML414, is a a cell-permeable inhibitor of oligosaccharyltransferase (OST). In non-small-cell lung cancer cell lines that are dependent on EGFR, OST inhibition causes cell-cycle arrest accompanied by induction of p21, autofluorescence, and cell morphology changes.
1: Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030. doi: 10.1038/nchembio.2194. Epub 2016 Oct 3. PubMed PMID: 27694802; PubMed Central PMCID: PMC5393272.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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