NGI-1 (ML414)

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Chemical Information

Product name：NGI-1 (ML414)	Purity：98% min
CAS NO：790702-57-7	Solubility：DMSO : 160 mg/mL (405.57 mM)
Molecular Formula：C₁₇H₂₂N₄O₃S₂	Package：Package according to customer requirements
Molecular Weight：394.51	Storage：Store at -20℃

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Remarks

NGI-1, also known s ML414, is a a cell-permeable inhibitor of oligosaccharyltransferase (OST). In non-small-cell lung cancer cell lines that are dependent on EGFR, OST inhibition causes cell-cycle arrest accompanied by induction of p21, autofluorescence, and cell morphology changes.

Synonyms:

5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide;

NGI-1;

Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-;

Antiviral Inhibitors Related Products:

Vadimezan; Geldanamycin; UNC0638; U0126-EtOH; Tenofovir; Baloxavir; Tubacin; Emricasan; Remdesivir; Baloxavir marboxil; Famciclovir; Epigoitrin ; Ribavirin

References

1: Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030. doi: 10.1038/nchembio.2194. Epub 2016 Oct 3. PubMed PMID: 27694802; PubMed Central PMCID: PMC5393272.