Tubacin

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Chemical Information

Product name：Tubacin	Purity：98% min
CAS NO：537049-40-4	Solubility：DMSO : ≥ 100 mg/mL (138.53 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₄₁H₄₃N₃O₇S	Package：Package according to customer requirements
Molecular Weight：721.861	Storage：Store at -20℃

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Remarks

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. The IC50 for other HDACs is 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Tubacin inhibits alpha-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6.

Antiviral Inhibitors Related Products:

Vadimezan; Geldanamycin; UNC0638; U0126-EtOH; Tenofovir; Baloxavir; NGI-1(ML414); Emricasan; Remdesivir; Baloxavir marboxil; Famciclovir; Epigoitrin ; Ribavirin

References

[1]. Butler KV, et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.

[2]. Hideshima T, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. Epub 2005 Jun 3.