CHIR-99021

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：CHIR-99021	Purity：98% min
CAS NO：252917-06-9	Solubility：DMSO : ≥ 5.1 mg/mL (10.96 mM)
Molecular Formula：C₂₂H₁₈Cl₂N₈	Package：Package according to customer requirements
Molecular Weight：465.338	Storage：Store at -20℃

Quality control

Remarks

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.

GSK-3 Inhibitors Related Prodcuts:

TWS119; AR-A014418; TDZD-8; 2-D08; BIO-Acetoxime; 5-Bromoindole; CP21R7 (CP21); SB-216763

References

[1]. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

[2]. Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004.

[3]. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273.