SB-216763

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Chemical Information

Product name：SB-216763	Purity：98% min
CAS NO：280744-09-4	Solubility：DMSO : 100 mg/mL (269.38 mM)
Molecular Formula：C₁₉H₁₂Cl₂N₂O₂	Package：Package according to customer requirements.
Molecular Weight：371.217	Storage：Store at -20℃

Quality control

COA

Remarks

SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, which can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). SB-216763 is the first GSK3 inhibitor that can promote self-renewal of mESC co-cultured with MEFs for more than two months.

Properties:
Density: 1.47 g/cm3
Melting Point: 287-288.6ºC(lit.)
Boiling Point: 598.1ºC at 760 mmHg
Flash Point: 315.5ºC
Refractive Index: 1.701

GSK-3 Inhibitors Related Prodcuts:

TWS119; CHIR-99021; AR-A014418; TDZD-8; 2-D08; BIO-Acetoxime; 5-Bromoindole; CP21R7 (CP21)

References

[1]. Gurrieri, et al. 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. J.Pharmacol.Exp.Ther.2010

[2]. Kirby LA, et al. Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.PLoS One. 2012;7(6):e39329. Epub 2012 Jun 26.