CP21R7 CP21

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Chemical Information

Product name：CP21R7 CP21	Purity：99% min
CAS NO：125314-13-8	Solubility：DMSO : ≥ 32 mg/mL (100.84 mM)
Molecular Formula：C₁₉H₁₅N₃O₂	Package：Package according to customer requirements
Molecular Weight：317.341	Storage：Store at -20℃

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Remarks

CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.

Synonyms:

3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;

3-(3-Amino-phenyl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione;

3-(1-methylindol-3-yl)-4-(3-aminophenyl)-1H-pyrrole-2,5-dione;

GSK-3 Inhibitors Related Prodcuts:

TWS119; CHIR-99021; AR-A014418; TDZD-8; 2-D08; BIO-Acetoxime; 5-Bromoindole; SB-216763

References

[1]. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6.

[2]. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003.