GSK-3 inhibitor X BIO-Acetoxime

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Chemical Information

Product name：GSK-3 inhibitor X BIO-Acetoxime	Purity：98% min
CAS NO：667463-85-6	Solubility：DMSO : 20.83 mg/mL (52.31 mM)
Molecular Formula：C₁₈H₁₂BrN₃O₃	Package：Package according to customer requirements
Molecular Weight：398.210	Storage：Store at -20℃

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Remarks

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation. BIO-acetoxime is a synthetic derivative of a compound from the Mediterranean mollusk Hexaplex trunculus. BIO-Acetoxime protects cells from varicella infection. BIO-acetoxime may suppress viral gene expression and protect oral epithelial cells from HSV-1 infection.

GSK-3 Inhibitors Related Prodcuts:

TWS119; CHIR-99021; AR-A014418; TDZD-8; 2-D08; 5-Bromoindole; CP21R7 (CP21); SB-216763

References

[1]. Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66.

[2]. Hsu MJ, et al. Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells. Arch Virol. 2013 Jun;158(6):1287-96.