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Pritelivir (BAY 57-1293)

Pritelivir (BAY 57-1293) 348086-71-5
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Chemical Information
Product name:Pritelivir (BAY 57-1293) Purity:98%min
CAS NO:348086-71-5 Solubility:Soluble in DMSO
Molecular Formula:C18H18N4O3S2 Package:Packaging according to customer requirements
Molecular Weight:402.49 Storage:Store at -20℃
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Remarks

Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.

The mechanism of action is that BAY 57-1293 directly inhibits the ATPase activity of the viral helicase-primase enzyme complex in a dose-dependent manner. BAY 57-1293 also shows potent antiviral activity against acyclovir resistant HSV mutants. [1] BAY 57-1293 reduces Aβ and P-tau induced by herpes simplex virus type 1 in vero cells. [3]

BAY 57-1293 (p.o.) shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes (0.5 mg/kg), in a murine zosteriform spread model of cutaneous disease (15 mg/kg), and in a murine ocular herpes model. [2]

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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