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INNO-206 HCl salt

INNO-206 HCl salt 480998-12-7
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Chemical Information
Product name:INNO-206 HCl salt Purity:98% min
CAS NO:480998-12-7 Solubility:DMSO : 125 mg/mL (158.79 mM)
Molecular Formula:C37H43ClN4O13 Package:Package according to customer requirements.
Molecular Weight:787.209 Storage:Store at -20℃
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Remarks

Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.

 

 

 

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