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Nimustine Hydrochloride

Nimustine Hydrochloride 55661-38-6
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Chemical Information
Product name:Nimustine Hydrochloride Purity:98% min
CAS NO:55661-38-6 Solubility:61 mg/mL (197.31 mM) in DMSO
Molecular Formula:C9H13ClN6O2.HCl Package:Packaging according to customer requirements
Molecular Weight:309.15 Storage:Store at -20℃
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Remarks
Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
References

1: Joss RA, Siegenthaler P, Ludwig C, Alberto P, Castiglione MM, Cavalli F. Phase II trial of nimustine (ACNU; 3-[4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride) in patients with small cell carcinoma of the lung after failure on combination chemotherapy. Invest New Drugs. 1986;4(2):175-9. PubMed PMID: 3015827.

2: Watanabe T, Katayama Y, Yoshino A, Fukaya C, Yamamoto T. Human interferon beta, nimustine hydrochloride, and radiation therapy in the treatment of newly diagnosed malignant astrocytomas. J Neurooncol. 2005 Mar;72(1):57-62. PubMed PMID: 15803376.

3: Zhang R, Saito R, Mano Y, Kanamori M, Sonoda Y, Kumabe T, Tominaga T. Concentration rather than dose defines the local brain toxicity of agents that are effectively distributed by convection-enhanced delivery. J Neurosci Methods. 2014 Jan 30;222:131-7. doi: 10.1016/j.jneumeth.2013.11.004. Epub 2013 Nov 20. PubMed PMID: 24269253.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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