Cyproterone acetate

Cyproterone acetate is an antiandrogen, i.e. it suppresses the actions of testosterone (and its metabolite dihydrotestosterone) on tissues. It acts by blocking androgen receptors which prevents androgens from binding to them and suppresses luteinizing hormone (which in turn reduces testosterone levels). Its main indications are prostate cancer, benign prostatic hyperplasia, priapism, hypersexuality and other conditions in which androgen action maintains the disease process. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transsexual people.

Properties:

Appearance & Physical State: Odour

Density: 1.27 g/cm3

Boiling Point: 525.9ºC at 760 mmHg

Melting Point: 200-201ºC

Flash Point: 177.6ºC

Refractive Index: 1.582

Androgen Receptor Inhibitors Related Products:

Chlormadinone acetate; Bicalutamide; Apalutamide; Galeterone; AZD-3514; Spironolactone; ARV-110; Darolutamide; Megestrol Acetate; Clascoterone; RU-58841; Enzalutamide

[1]. Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83(1): p. 136-48.

[2]. Attardi, B.J., S. Koduri, and S.A. Hild, Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell End

[3]. Arafa, N.M., Efficacy of echinacea on the action of cyproterone acetate in male rats. Pak J Biol Sci, 2010. 13(20): p. 966-76.