Bicalutamide

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Chemical Information

Product name：Bicalutamide	Purity：98% min
CAS NO：90357-06-5	Solubility：DMSO : ≥ 50 mg/mL (116.18 mM)
Molecular Formula：C₁₈H₁₄F₄N₂O₄S	Package：Package according to customer requirements
Molecular Weight：430.373	Storage：Store at -20℃

Quality control

COA

Remarks

Bicalutamide is a synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors.

Properties:

Appearance & Physical State: off-white crystalline solid

Density: 1.52 g/cm3

Boiling Point: 650.3ºC at 760 mmHg

Melting Point: 191-193ºC

Flash Point: 347.1ºC

Refractive Index: 1.577

Androgen Receptor Inhibitors Related Products:

Chlormadinone acetate; Apalutamide; Galeterone; Cyproterone acetate; AZD-3514; Spironolactone; ARV-110; Darolutamide; Megestrol Acetate; Clascoterone; RU-58841; Enzalutamide

References

[1]. Nicola J. Clegg,1 John Wongvipat,1,2 Jim Joseph, ARN-509: a novel anti-androgen for prostate cancer treatment. Cancer Res. 2012 March 15; 72(6): 1494-1503.

[2]. RACHEL M. SQUILLACE, DAVID MILLER, SCOTT D. WARDWELL, Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models. Int J Oncol. 2012 August; 41(2): 425-432.

[3]. Nakabayashi M, Werner L, Courtney KD, Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer. BJU Int. 2012 Dec;110(11):1729-35.