Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria.It is the first member of a new class of drugs called the diarylquinolines. Bedaquiline is bactericidal.
Properties:
Density: 1.344 g/cm3
Boiling Point: 456.78ºC at 760 mmHg
Flash Point: 230.052ºC
ATPase Inhibitors Related Products:
Omecamtiv mecarbil; Brefeldin A; Lansoprazole; PF-03716556; Dexlansoprazole; CB-5083; Bafilomycin A1; Tamoxifen; Oleandrin; Esomeprazole sodium; Oligomycin A