Omecamtiv mecarbil

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Chemical Information

Product name：Omecamtiv mecarbil	Purity：98% min
CAS NO：873697-71-3	Solubility：DMSO : 50 mg/mL (124.55 mM)
Molecular Formula：C₂₀H₂₄FN₅O₃	Package：Package according to customer requirements.
Molecular Weight：401.435	Storage：Store at -20℃

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Remarks

Omecamtiv mecarbil, also known as CK-1827452, is a cardiac specific myosin activator. It is clinically tested for its role in the treatment of left ventricular systolic heart failure. Omecamtiv Mecarbil specifically targets and activates myocardial ATPase and improves energy utilization. Omecamtiv Mecarbil improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.

Properties:

Density: 1.344 g/cm3

Boiling Point: 456.78ºC at 760 mmHg

Flash Point: 230.052ºC

ATPase Inhibitors Related Products:

Brefeldin A; Lansoprazole; PF-03716556; Dexlansoprazole; CB-5083; Bedaquiline; Bafilomycin A1; Tamoxifen; Oleandrin; Esomeprazole sodium; Oligomycin A

References

[1]. Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1(9):472-7.

[2]. Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.