Butenafine Hydrochloride

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Chemical Information

Product name：Butenafine Hydrochloride	Purity：98% min
CAS NO：101827-46-7	Solubility：DMSO : 25 mg/mL (70.64 mM)
Molecular Formula：C₂₃H₂₈ClN	Package：Package according to customer requirements
Molecular Weight：353.928	Storage：Store at -20℃

Quality control

Remarks

Butenafine hydrochloride is an odorless white crystalline powder that is freely soluble in methanol, ethanol, and chloroform, and slightly soluble in water. Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak out.

Properties:
Appearance & Physical State: White crystalline powder
Density: 1.032g/cm3
Melting Point: 210-214ºC
Boiling Point: 426.1ºC at 760 mmHg
Flash Point: 187.7ºC
Vapor Pressure: 1.82E-07mmHg at 25°C

Fungal Inhibitors Related Products:

Miconazole nitrate; AN2718; Terbinafine HCl; Liranaftate; Fenticonazole Nitrate; Amorolfine HCl; Tioconazole; Butoconazole nitrate; Tavaborole; Cicloheximide; Luliconazole; Efinaconazole; Isavuconazole; Micafungin sodium; Micafungin

References

[1]. Singal A. Butenafine and superficial mycoses: current status. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):999-1005.

[2]. Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003 Sep;42 Suppl 1:11-7.