Miconazole nitrate

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Chemical Information

Product name：Miconazole nitrate	Purity：98% min
CAS NO：22832-87-7	Solubility：DMSO : 50 mg/mL (104.35 mM)
Molecular Formula：C₁₈H₁₅Cl₄N₃O₄	Package：Package according to customer requirements
Molecular Weight：479.141	Storage：Store at -20℃

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Remarks

Miconazole nitrate is an 14-α demethylase inhibitor and potential glucocorticoid receptor antagonist that inhibits ergosterol synthesis and fungal cell wall formation. It is used to treat fungal infections and is especially active against Candida. It also decreases expression of HIF-1α and VEGF in breast cancer and glioma cells.

Properties:
Appearance & Physical State: White crystal powder
Density: 1.451g/cm3
Melting Point: 170-185ºC
Boiling Point: 555.1ºC at 760 mmHg
Flash Point: 289.5ºC

Fungal Inhibitors Related Products:

AN2718; Terbinafine HCl; Liranaftate; Fenticonazole Nitrate; Amorolfine HCl; Tioconazole; Butoconazole nitrate; Tavaborole; Cicloheximide; Luliconazole; Efinaconazole; Isavuconazole; Micafungin sodium; Micafungin; Butenafine hydrochloride

References

1: Birsan M, Cojocaru I, Scutariu MM, Popovici I. Research studies on in vitro and ex vivo yield of the miconazole nitrate from oral biomucoadhesive tablets. Rev Med Chir Soc Med Nat Iasi. 2014 Jan-Mar;118(1):225-31. PubMed PMID: 24741805.

2: Fan S, Liu X, Liang Y. Miconazole nitrate vaginal suppository 1,200 mg versus oral fluconazole 150 mg in treating severe vulvovaginal candidiasis. Gynecol Obstet Invest. 2015;80(2):113-8. doi: 10.1159/000371759. Epub 2015 Feb 17. PubMed PMID: 25720546.