CYM50308

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Chemical Information

Product name：CYM50308	Purity：98% min
CAS NO：1345858-76-5	Solubility：DMSO : 12 mg/mL (29.60 mM)
Molecular Formula：C₂₀H₂₁F₂N₃O₂S	Package：Package according to customer requirements
Molecular Weight：405.461	Storage：-20℃

Quality control

Remarks

CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM.

Properties:

Boiling point: 504.0±60.0 °C(Predicted)

density: 1.28±0.1 g/cm3(Predicted)

pka: 0.47±0.20(Predicted)

LPL Receptor Related Products:

Ki16425; Ki16198; AM095; Fingolimod hydrochloride; Siponimod; Ozanimod; CYM5520; JTE-013; Ponesimod; Etrasimod; AM966; NIBR-0213; VPC-23019; ONO-7300243

References

[1]. Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45.