CYM-5520 is a pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. The compound CYM-5520 does not show any agonsit activity towards S1PR1, S1PR3, S1PR4 or S1PR5. It acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).
Synonyms:
1-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile;
3-Pyridinecarbonitrile, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-;
Properties:
Boiling point: 580.5±50.0 °C(Predicted)
density: 1.16±0.1 g/cm3(Predicted)
form: powder
pka: -2.80±0.70(Predicted)
color: white to beige
LPL Receptor Related Products:
Ki16425; Ki16198; AM095; Fingolimod hydrochloride; Siponimod; Ozanimod; JTE-013; Ponesimod; Etrasimod; AM966; CYM50308; NIBR-0213; VPC-23019; ONO-7300243