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AZD3463

AZD3463 1356962-20-3
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Chemical Information
Product name:AZD3463 Purity:98% min
CAS NO:1356962-20-3 Solubility:10 mM in DMSO
Molecular Formula:C24H25ClN6O Package:Package according to customer requirements
Molecular Weight:448.948 Storage:Store at -20℃
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Remarks
AZD-3463 is a potent ALK/IGF1R inhibitor with potential anticancer activity. AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. AZD3463 effectively suppressed the proliferation of NB cell lines with wild type ALK (WT) as well as ALK activating mutations (F1174L and D1091N) by blocking the ALK-mediated PI3K/AKT/mTOR pathway and ultimately induced apoptosis and autophagy. In addition, AZD3463 enhanced the cytotoxic effects of doxorubicin on NB cells. AZD3463 also exhibited significant therapeutic efficacy on the growth of the NB tumors with WT and F1174L activating mutation ALK in orthotopic xenograft mouse models.
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