BMS-536924

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Chemical Information

Product name：BMS-536924	Purity：98% min
CAS NO：468740-43-4	Solubility：DMSO : 50 mg/mL (104.18 mM)
Molecular Formula：C₂₅H₂₆ClN₅O₃	Package：Package according to customer requirements
Molecular Weight：479.959	Storage：Store at -20℃

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Remarks

BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity.

Synonyms:

CHEMBL401930;

4-[[(2S)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]-3-[7-METHYL-5-(4-MORPHOLINYL)-1H-BENZIMIDAZOL-2-YL]-2(1H)-PYRIDINONE;

INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR INHIBITOR;

IGF-1R Inhibitors Related Products:

Luminespib; NVP-AEW541; GSK1904529A; Ceritinib; AG-1024; PQ401; AZD3463; Picropodophyllin; XL228; MSDC-0160; Linsitinib

References

[1]. Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48(18):5639-43.

[2]. Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15(1):226-37.