AG-1024 Tyrphostin

AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.

Properties:

Density: 1.42g/cm3

Boiling Point: 379.8ºC at 760 mmHg

Flash Point: 183.5ºC

Refractive Index: 1.609

IGF-1R Inhibitors Related Products:

Luminespib; NVP-AEW541; GSK1904529A; BMS-536924; Ceritinib; PQ401; AZD3463; Picropodophyllin; XL228; MSDC-0160; Linsitinib

[1]. Párrizas M, et al. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33.

[2]. Wen B, et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer. 2001 Dec 14;85(12):2017-21.