Welcome to Crene Biotechnology!

+86-576-88205808

Product :

GSK1904529A

GSK1904529A 1089283-49-7
Size Price Stock Quantity
Get Quotation Now Add to Cart Bulk Inquiry
Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Chemical Information
Product name:GSK1904529A Purity:98% min
CAS NO:1089283-49-7 Solubility:DMSO : 50 mg/mL (58.69 mM)
Molecular Formula:C44H47F2N9O5S Package:Package according to customer requirements
Molecular Weight:851.963 Storage:Store at -20℃
Quality control
COA
Remarks

GSK-1904529A, also known as GSK 4529, is an IGF-1R Inhibitor, is is a promising candidate for therapeutic use in IGF-IR–dependent tumors. GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively. GSK1904529A blocks receptor autophosphorylation and downstream signaling, leading to cell cycle arrest. It inhibits the proliferation of cell lines derived from solid and hematologic malignancies, with multiple myeloma and Ewing's sarcoma cell lines being most sensitive. Oral administration of GSK1904529A decreases the growth of human tumor xenografts in mice, consistent with a reduction of IGF-IR phosphorylation in tumors. Despite the potent inhibitory activity of GSK1904529A on IR in vitro and in vivo , minimal effects on blood glucose levels are observed in animals at doses that show significant antitumor activity. 

 

 

 

IGF-1R Inhibitors Related Products:

Luminespib; NVP-AEW541; BMS-536924; Ceritinib; AG-1024; PQ401; AZD3463; Picropodophyllin; XL228; MSDC-0160; Linsitinib

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Friendly link:

Copyright Copyright (C) 2018-2024 Taizhou Crene Biotechnology Co.,Ltd.  

Address:Economic Developed Zone of Taizhou Zhejiang China