Picropodophyllin

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Chemical Information

Product name：Picropodophyllin	Purity：98% min
CAS NO：477-47-4	Solubility：DMSO : 50 mg/mL (120.65 mM)
Molecular Formula：C₂₂H₂₂O₈	Package：Package according to customer requirements
Molecular Weight：414.405	Storage：Store at 2-8ºC

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Remarks

Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis.

Properties:
Density: 1.37g/cm3
Melting Point: 225-227ºC
Boiling Point: 597.9ºC at 760mmHg
Flash Point: 210.2ºC
Refractive Index: 1.605

IGF-1R Inhibitors Related Products:

Luminespib; NVP-AEW541; GSK1904529A; BMS-536924; Ceritinib; AG-1024; PQ401; AZD3463; XL228; MSDC-0160 ; Linsitinib

References

[1]. Girnita A, et al. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 Jan 1;64(1):236-42.

[2]. Menu E, et al. Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood. 2006 Jan 15;107(2):655-60. Epub 2005 Jul 26.

[3]. Bieghs L, et al. The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic. Oncotarget. 2014 Nov 30;5(22):11193-208.