PQ401 is a potent and selective IGF-1R inhibitor. PQ-401 induces apoptosis and inhibits growth, proliferation and migration of glioma cells. PQ401 not only induced cellular apoptosis in U87MG cells and subsequently reduced cell viability and proliferation but also attenuated cell mobility in vitro. More importantly, through a mouse xenograft model, administration of PQ401 on mice led to suppression of glioma tumour growth in vivo. PQ401 may serve as a promising leading drug for treating glioma patients with elevated IGF-1R signalling.
Synonyms:
IGF-1R Inhibitor II;
UNII-2N3LV83S8J;
1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea;
N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl);
IGF-1R Inhibitors Related Products:
Luminespib; NVP-AEW541; GSK1904529A; BMS-536924; Ceritinib; AG-1024; AZD3463; Picropodophyllin; XL228; MSDC-0160; Linsitinib