Metarrestin (ML246)

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Chemical Information

Product name：Metarrestin (ML246)	Purity：98% min
CAS NO：1443414-10-5	Solubility：DMSO : 31.25 mg/mL (65.84 mM)
Molecular Formula：C₃₁H₃₀N₄O	Package：Package according to customer requirements
Molecular Weight：474.596	Storage：-20 ℃

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Remarks

Metarrestin (ML246) is an orally active, specific perinucleolar compartment inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.

Related Prodcuts:

Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; Carmustine; CX-5461; Nelarabine; Cladribine; Trifluridine; Daptomycin; Fludarabine Phosphate

References

[1]. Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080.
[2]. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).